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ClinicalTrials.gov

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ClinicalTrials.gov study registry (via CTTI AACT)

ClinicalTrials.gov is the U.S. NIH registry and results database of clinical studies conducted around the world. This MCP lets an AI assistant search, retrieve, and aggregate trial records — by condition, intervention, sponsor, phase, status, and location — sourced from CTTI's AACT database, which mirrors ClinicalTrials.gov and is refreshed daily. Beyond keyword search, it also lets an assistant search by meaning — finding relevant trials by concept even when the wording differs.

Connect

MCP endpoint
https://mcp.polarisray.com/clinical_trials

Transport: http · Auth: none · See the connection guide for client-specific steps.

Tools

  • search_studies Search studies by free text and filters — condition, intervention, sponsor, status, phase, study type, country, or start-date range.
  • semantic_search_studies Search studies by meaning, not just exact keywords — finds relevant trials by concept.
  • get_study Retrieve the full record for a single study by its NCT id.
  • aggregate_studies Count and group studies by status, phase, study type, country, year, condition, sponsor, or intervention — or as a time trend.
  • top_terms Surface the most common conditions, interventions, or sponsors across a matching set of studies.
  • resolve Normalize lay terms, synonyms, and abbreviations to standard medical terms (e.g. "heart attack" → "Myocardial Infarction") for precise filtering.

Example questions

  • "How many Phase 3 trials for glioblastoma are recruiting right now?"
  • "Find trials about gene therapy for inherited blindness."
  • "Show recent interventional studies sponsored by Pfizer, newest first."
  • "What are the most-studied conditions in trials that started in 2024?"
  • "Find trials of semaglutide for heart failure with sites in the United States."

About this dataset

ClinicalTrials.gov is the NIH-maintained registry and results database of publicly and privately supported clinical studies conducted around the world. This connector is backed by the AACT database from the Clinical Trials Transformation Initiative (CTTI), a relational mirror of ClinicalTrials.gov that is rebuilt daily — so answers reflect the registry as of the latest nightly load.

What you can ask

Ask plain-English questions and the assistant translates them into structured searches: filter by condition, intervention (drug/device/procedure), sponsor, recruitment status, phase, study type, country, and start date; retrieve a full study record by its NCT id; or aggregate across the registry to see trends, top conditions, or the most active sponsors. Hits include an official url to the ClinicalTrials.gov study page.

Search by meaning

In addition to keyword search, you can search studies by meaning rather than exact words. Ask for studies “about” or “similar to” a topic and it surfaces conceptually related trials even when the phrasing differs — and all the usual filters (phase, status, condition, …) still apply.

Caveats

Trial registration is not endorsement. Records vary in completeness and timeliness, sponsors self-report much of the data, and counts should be treated as signals rather than definitive statistics. Always confirm details against the primary study record on ClinicalTrials.gov before drawing conclusions, and never treat registry data as medical advice.

Why PolarisRay

Fewer tokens. Search by meaning.

Answer-ready results with far less context than raw APIs — plus concept search the official FDA API can't do.

See why PolarisRay →